Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jan;83(1):137-42.
doi: 10.1172/JCI113849.

Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis

H G Kraft  1 , H J Menzel, F Hoppichler, W Vogel, G Utermann
Affiliations

Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis

H G Kraft et al. J Clin Invest. 1989 Jan.

Abstract

Liver transplantation provides a unique opportunity to investigate the contribution in vivo of the liver to the synthesis and degradation of genetically polymorphic plasma proteins. We have determined the genetic polymorphisms plasma proteins. We have determined the genetic polymorphisms of apo A-IV, apo E, and of the Lp(a) glycoprotein (apo (a] in the plasma of subjects undergoing liver transplantation and in respective organ donors. The results show that in humans, greater than 90% of the plasma apo E and virtually all apo (a) are liver derived, whereas this organ does not significantly contribute to plasma apo A-IV levels.

PubMed Disclaimer

References

    1. J Biol Chem. 1983 Apr 10;258(7):4582-9 - PubMed
    1. Hum Genet. 1982;62(4):349-52 - PubMed
    1. J Lipid Res. 1984 Apr;25(4):378-82 - PubMed
    1. J Biol Chem. 1984 Sep 25;259(18):11470-8 - PubMed
    1. N Engl J Med. 1984 Dec 27;311(26):1658-64 - PubMed

Publication types