doi: 10.1002/adhm.201400249.
Epub 2014 Sep 11.
Inhibition of angiogenesis by antioxidant micelles
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- PMID: 25213436
- DOI: 10.1002/adhm.201400249
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Inhibition of angiogenesis by antioxidant micelles
Adv Healthc Mater.
.
Abstract
Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer.
Keywords: angiogenesis; antioxidants; drug delivery; micelles; oxidation.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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