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. 2015 Mar 11;4(4):569-75.
doi: 10.1002/adhm.201400249. Epub 2014 Sep 11.

Inhibition of angiogenesis by antioxidant micelles

Masaki Moriyama  1 , Stéphanie Metzger, André J van der Vlies, Hiroshi Uyama, Martin Ehrbar, Urara Hasegawa
Affiliations

Inhibition of angiogenesis by antioxidant micelles

Masaki Moriyama et al. Adv Healthc Mater. .

Abstract

Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer.

Keywords: angiogenesis; antioxidants; drug delivery; micelles; oxidation.

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