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Case Reports
. 2014 Sep 11:2014:bcr2014204013.
doi: 10.1136/bcr-2014-204013.

Risk of statin-induced rhabdomyolysis in patients with hepatic impairment

Nitin Kolhe  1 , Jeremy Lewis  1 , Thomas Alasdair McCulloch  2
Affiliations
Case Reports

Risk of statin-induced rhabdomyolysis in patients with hepatic impairment

Nitin Kolhe et al. BMJ Case Rep. .

Abstract

We describe a case of a 54-year-old man with a 2-month history of biliary colic associated with a common bile duct stone. He underwent laparoscopic cholecystectomy and developed postoperative acute kidney injury stage 3. A renal biopsy was performed and demonstrated myoglobin in the renal tubules. Retrospective creatine kinase analysis was suggestive of rhabdomyolysis. It is thought this was precipitated by simvastatin accumulation in the context of a period of hepatic impairment and elevated liver enzymes.

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Figures

Figure 1
Figure 1
Renal biopsy specimen with H&E staining, demonstrating acute tubular injury.
Figure 2
Figure 2
Renal biopsy specimen with immunoperoxidase staining for myoglobin in renal tubule.
See this image and copyright information in PMC

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