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Editorial
. 2014 Sep 12;115(7):602-4.
doi: 10.1161/CIRCRESAHA.114.304854.

Sorting out where fibroblasts come from

Thomas Moore-Morris  1 , Michelle D Tallquist  1 , Sylvia M Evans  2
Affiliations
Editorial

Sorting out where fibroblasts come from

Thomas Moore-Morris et al. Circ Res. .
No abstract available

Keywords: Editorials; fibroblasts; fibrosis; pericardium.

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Conflict of interest statement

Conflicts of interest: None.

Figures

Figure 1
Figure 1
Previous studies have proposed that cardiac fibroblasts derive from epicardium during development, while large numbers of fibroblasts are generated by endothelial-to-mesenchymal transition (EndoMT) and recruitment of blood cells following pressure overload. The study by Ali et al. shows that Tie2-Cre tagged Thy1+ HE- (HE, hematopoietic and endothelial lineage) fibroblasts are present alongside epicardially derived Tbx18-Cre lineage traced Thy1+ HE- fibroblasts in healthy myocardium. These developmentally derived subsets proliferate following aortic banding, leading to fibrosis. There was no evidence for endothelial-to-mesenchymal transition (EndoMT) or conversion of hematopoietic progenitors into fibroblasts.
See this image and copyright information in PMC

Comment on

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