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. 2014:2014:630712.
doi: 10.1155/2014/630712. Epub 2014 Aug 19.

Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

Włodzimierz Luczyński  1 , Wojciech Fendler  2 , Anna Ramatowska  3 , Agnieszka Szypowska  3 , Agnieszka Szadkowska  2 , Wojciech Młynarski  2 , Miron Chumiecki  4 , Przemysława Jarosz-Chobot  4 , Joanna Chrzanowska  5 , Anna Noczyńska  5 , Agnieszka Brandt  6 , Małgorzata Myśliwiec  6 , Barbara Głowińska-Olszewska  1 , Paweł Bernatowicz  7 , Oksana Kowalczuk  8 , Artur Bossowski  1
Affiliations

Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

Włodzimierz Luczyński et al. Int J Endocrinol. 2014.

Abstract

The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4-18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P = 0.0003), poor metabolic control (P = 0.0001), and carriage of the A allele of the FTO rs9939609 gene (P = 0.02). Conclusion. Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161).

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Figures

Figure 1
Figure 1
The influence of tested polymorphic variants on standardized BMI (BMI-SDS) in children with type 1 diabetes. D: difference of means, 95% CI: 95% confidence interval, and WT: wild-type.
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