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. 2014 Aug;48(4):335-8.
doi: 10.4132/KoreanJPathol.2014.48.4.335. Epub 2014 Aug 26.

Usefulness of Nuclear Protein in Testis (NUT) Immunohistochemistry in the Cytodiagnosis of NUT Midline Carcinoma: A Brief Case Report

Heae Surng Park  1 , Yoon Sung Bae  1 , Sun Och Yoon  1 , Beom Jin Lim  1 , Hyun Jun Hong  2 , Jae Y Ro  3 , Soon Won Hong  1
Affiliations

Usefulness of Nuclear Protein in Testis (NUT) Immunohistochemistry in the Cytodiagnosis of NUT Midline Carcinoma: A Brief Case Report

Heae Surng Park et al. Korean J Pathol. 2014 Aug.
No abstract available

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Radiologic findings. Neck magnetic resonance imaging reveals an infiltrative mass (arrow) with strong gadolinium enhancement, located in the deep fat layer of the right cheek.
Fig. 2
Fig. 2
Cytologic findings. (A) The smear shows many cohesive clusters with single scattered cells. (B) Tumor cell necrosis is found. (C) The tumor cells are relatively small and uniform with irregular ovoid nuclei, small nucleoli, and occasional mitosis. (D) NUT immunohistochemistry (C52) using the aspirated smear slide reveals diffuse nuclear immunoreactivity.
Fig. 3
Fig. 3
Histopathologic findings. (A) The tumor is composed of sheets of poorly differentiated cells with desmoplastic stroma. (B, C) The tumor cells have relatively small and irregular ovoid nuclei with small nucleoli. Individual cell necrosis (arrow), frequent mitosis, and tiny necrotic foci (arrowhead) are present. Immunohistochemical stains reveal diffuse nuclear immunoreactivity to p63 (D) and the NUT specific antibody (E).
See this image and copyright information in PMC

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