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. 2013;4(3):205-9.
doi: 10.5847/wjem.j.issn.1920-8642.2013.03.009.

Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times

Ming Liu  1 , Hai-Rong Wang  1 , Jia-Fu Liu  1 , Hao-Jun Li  1 , Shen-Xing Chen  1 , Sha Shen  1 , Shu-Ming Pan  1
Affiliations

Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times

Ming Liu et al. World J Emerg Med. 2013.

Abstract

Background: The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) on the onset of acute cerebral infarction (ACI) at different time points of the first 6 hours.

Methods: A retrospective analysis was conducted in 74 patients who received rt-PA thrombolysis treatment within 4.5 hours after ACI and another 15 patients who received rt-PA thrombolysis treatment between 4.5-6 hours after ACI.

Results: National Institute of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P>0.05) at 24 hours and 7 days after ACI. There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups (P>0.05).

Conclusions: The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rt-PA within 4.5 hours after the onset of this disease. Therefore, intravenous thrombolytic therapy for ACI within 4.5-6 hours after ACI was effective and safe.

Keywords: Acute cerebral infarction; Recombinant tissue type plasminogen activator; Thrombolysis.

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Conflict of interest statement

Conflicts of interest: The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of NIHSS scores between the two groups before and after thrombolysis. Compared within the same group, *P< 0.05.
Figure 2
Figure 2
Comparison of decrease of NIHSS scores of patients after thrombolysis between the two groups. *P<0.05, #P>0.05.
Figure 3
Figure 3
Modified Rankin scores of patients in the two groups 90 days after thrombolysis. *P>0.05.
See this image and copyright information in PMC

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