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Review
. 2013;4(4):245-51.
doi: 10.5847/wjem.j.issn.1920-8642.2013.04.001.

Safety of epinephrine for anaphylaxis in the emergency setting

Joseph P Wood  1 , Stephen J Traub  1 , Christopher Lipinski  1
Affiliations
Review

Safety of epinephrine for anaphylaxis in the emergency setting

Joseph P Wood et al. World J Emerg Med. 2013.

Abstract

Background: While epinephrine is the recommended first-line therapy for the reversal of anaphylaxis symptoms, inappropriate use persists because of misunderstandings about proper dosing and administration or misconceptions about its safety. The objective of this review was to evaluate the safety of epinephrine for patients with anaphylaxis, including other emergent conditions, treated in emergency care settings.

Methods: A MEDLINE search using PubMed was conducted to identify articles that discuss the dosing, administration, and safety of epinephrine in the emergency setting for anaphylaxis and other conditions.

Results: Epinephrine is safe for anaphylaxis when given at the correct dose by intramuscular injection. The majority of dosing errors and cardiovascular adverse reactions occur when epinephrine is given intravenously or incorrectly dosed.

Conclusion: Epinephrine by intramuscular injection is a safe therapy for anaphylaxis but training may still be necessary in emergency care settings to minimize drug dosing and administration errors and to allay concerns about its safety.

Keywords: Allergy; Anaphylaxis; Cardiovascular side effects; Epinephrine; Safety.

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Conflict of interest statement

Conflicts of interest: We have no conflicts of interest to report.

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References

    1. Wang J, Sicherer SH, Nowak-Wegrzyn A. Primary care physicians’ approach to food-induced anaphylaxis: a survey. J Allergy Clin Immunol. 2004;114:689–691. - PubMed
    1. Krugman SD, Chiaramonte DR, Matsui EC. Diagnosis and management of food-induced anaphylaxis: a national survey of pediatricians. Pediatrics. 2006;118:e554–560. - PubMed
    1. Patel BM, Bansal PJ, Tobin MC. Management of anaphylaxis in child care centers: evaluation 6 and 12 months after an intervention program. Ann Allergy Asthma Immunol. 2006;97:813–815. - PubMed
    1. Gaeta TJ, Clark S, Pelletier AJ, Camargo CA. National study of US emergency department visits for acute allergic reactions, 1993 to 2004. Ann Allergy Asthma Immunol. 2007;98:360–365. - PubMed
    1. Wheeler DW, Carter JJ, Murray LJ, Degnan BA, Dunling CP, Salvador R, et al. The effect of drug concentration expression on epinephrine dosing errors: a randomized trial. Ann Intern Med. 2008;148:11–14. - PubMed

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