Nickel-catalyzed reductive cyclization of alkyl dihalides
- PMID: 25216275
- DOI: 10.1021/ol502207z
Nickel-catalyzed reductive cyclization of alkyl dihalides
Abstract
The reductive coupling protocol to intramolecular cyclization of dihaloalkanes is presented. It leads to five- and six-membered rings, with the former being more efficient. The incorporation of secondary alkyl halides generally promotes coupling efficiency. To the best of our knowledge, this is the first catalytic ring-closure reaction arising from dihaloalkanes under chemical reductive conditions.
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