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. 2014 Oct 3;16(19):4984-7.
doi: 10.1021/ol502207z. Epub 2014 Sep 12.

Nickel-catalyzed reductive cyclization of alkyl dihalides

Affiliations

Nickel-catalyzed reductive cyclization of alkyl dihalides

Weichao Xue et al. Org Lett. .

Abstract

The reductive coupling protocol to intramolecular cyclization of dihaloalkanes is presented. It leads to five- and six-membered rings, with the former being more efficient. The incorporation of secondary alkyl halides generally promotes coupling efficiency. To the best of our knowledge, this is the first catalytic ring-closure reaction arising from dihaloalkanes under chemical reductive conditions.

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