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. 2014 Dec 1;592(23):5153-67.
doi: 10.1113/jphysiol.2014.272955. Epub 2014 Sep 12.

Can Bayliss and Starling gut hormones cure a worldwide pandemic?

R V Scott  1 , T M Tan  2 , S R Bloom  2
Affiliations

Can Bayliss and Starling gut hormones cure a worldwide pandemic?

R V Scott et al. J Physiol. .

Abstract

Bayliss and Starling first coined the term 'hormone' with reference to secretin, a substance they found that was produced by the gut, but released into the blood stream to act at a distance. The intestine is now known as the largest endocrine organ in the body, and it produces numerous hormones with a wide range of functions. These include controlling appetite and energy homeostasis. Obesity is one of the greatest health threats facing the world today. At present, the only successful treatment is surgery. Bariatric procedures such as the Roux-en-Y bypass work by elevating gut hormones that induce satiety. Significant research has gone into producing versions of these hormones that can be delivered therapeutically to treat obesity. This review looks at the role of gut hormones in obesity, and the development of gut hormone-derived obesity treatments.

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Figures

Figure 1
Figure 1. Diagram of structures involved in control of food intake
Figure 2
Figure 2. Effect of i.c.v. GLP-1 on food intake
Reproduced from Turton et al. (1996) with permission from Macmillan Publishers Ltd.
Figure 3
Figure 3. Types of bypass surgery
See this image and copyright information in PMC

References

    1. Acosta A, Hurtado MD, Gorbatyuk O, La Sala M, Duncan D, Aslanidi G, Campbell-Thompson M, Zhang L, Herzog H, Voutetakis A, Baum BJ. Zolotukhin S. Salivary PYY: a putative bypass to satiety. PLoS One. 2011;6:e26137. &. - PMC - PubMed
    1. Adams SH, Lei C, Jodka CM, Nikoulina SE, Hoyt JA, Gedulin B, Mack CM. Kendall ES. J Nutr. 2006;136:195–201. &. - PubMed
    1. Adrian TE, Bloom SR, Bryant MG, Polak JM, Heitz PH. Barnes AJ. Distribution and release of human pancreatic polypeptide. Gut. 1976;17:940–944. &. - PMC - PubMed
    1. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM. Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology. 1985;89:1070–1077. &. - PubMed
    1. Arnelo U, Herrington MK, Theodorsson E, Adrian TE, Reidelberger R, Larsson J, Marcusson J, Strömmer L, Ding X. Permert J. Effects of long-term infusion of anorexic concentrations of islet amyloid polypeptide on neurotransmitters and neuropeptides in rat brain. Brain Res. 2000;887:391–398. &. - PubMed

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