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. 2014 Sep 12;106(10):dju255.
doi: 10.1093/jnci/dju255. Print 2014 Oct.

Prevalence of mammographically dense breasts in the United States

Brian L Sprague  1 , Ronald E Gangnon  2 , Veronica Burt  2 , Amy Trentham-Dietz  2 , John M Hampton  2 , Robert D Wellman  2 , Karla Kerlikowske  2 , Diana L Miglioretti  2
Affiliations

Prevalence of mammographically dense breasts in the United States

Brian L Sprague et al. J Natl Cancer Inst. .

Abstract

Background: National legislation is under consideration that would require women with mammographically dense breasts to be informed of their breast density and encouraged to discuss supplemental breast cancer screening with their health care providers. The number of US women potentially affected by this legislation is unknown.

Methods: We determined the mammographic breast density distribution by age and body mass index (BMI) using data from 1518 599 mammograms conducted from 2007 through 2010 at mammography facilities in the Breast Cancer Surveillance Consortium (BCSC). We applied these breast density distributions to age- and BMI-specific counts of the US female population derived from the 2010 US Census and the National Health and Nutrition Examination Survey (NHANES) to estimate the number of US women with dense breasts.

Results: Overall, 43.3% (95% confidence interval [CI] = 43.1% to 43.4%) of women 40 to 74 years of age had heterogeneously or extremely dense breasts, and this proportion was inversely associated with age and BMI. Based on the age and BMI distribution of US women, we estimated that 27.6 million women (95% CI = 27.5 to 27.7 million) aged 40 to 74 years in the United States have heterogeneously or extremely dense breasts. Women aged 40 to 49 years (N = 12.3 million) accounted for 44.3% of this group.

Conclusion: The prevalence of dense breasts among US women of common breast cancer screening ages exceeds 25 million. Policymakers and healthcare providers should consider this large prevalence when debating breast density notification legislation and designing strategies to ensure that women who are notified have opportunities to evaluate breast cancer risk and discuss and pursue supplemental screening options if deemed appropriate.

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Figures

Figure 1.
Figure 1.
Distribution of BI-RADS breast density categories by age, Breast Cancer Surveillance Consortium, 2007–2010. Proportions are standardized to the NHANES 2007–2010 age-specific distribution of body mass index among US women. BI-RADS = American College of Radiology’s Breast Imaging Reporting and Data System.
Figure 2.
Figure 2.
Distribution of BI-RADS breast density categories by body mass index, Breast Cancer Surveillance Consortium, 2007–2010. Proportions are standardized to the 2010 US Census age distribution among US women aged 40 years and older. BI-RADS = American College of Radiology’s Breast Imaging Reporting and Data System.
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References

    1. Boyd NF, Guo H, Martin LJ, et al. Mammographic density and the risk and detection of breast cancer. N Engl J Med. 2007;356(3):227–236 - PubMed
    1. Tice JA, Cummings SR, Smith-Bindman R, Ichikawa L, Barlow WE, Kerlikowske K. Using clinical factors and mammographic breast density to estimate breast cancer risk: development and validation of a new predictive model. Ann Intern Med. 2008;148(5):337–347 - PMC - PubMed
    1. Kerlikowske K, Grady D, Barclay J, Sickles EA, Ernster V. Effect of age, breast density, and family history on the sensitivity of first screening mammography. JAMA. 1996;276(1):33–38 - PubMed
    1. Buist DS, Porter PL, Lehman C, Taplin SH, White E. Factors contributing to mammography failure in women aged 40–49 years. J Natl Cancer Inst. 2004;96(19):1432–1440 - PubMed
    1. Carney PA, Miglioretti DL, Yankaskas BC, et al. Individual and combined effects of age, breast density, and hormone replacement therapy use on the accuracy of screening mammography. Ann Intern Med. 2003;138(3):168–175 - PubMed

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