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. 2014 Nov;102(5):1338-44.
doi: 10.1016/j.fertnstert.2014.07.1242. Epub 2014 Sep 11.

Using the Society for Assisted Reproductive Technology Clinic Outcome System morphological measures to predict live birth after assisted reproductive technology

Barbara Luke  1 , Morton B Brown  2 , Judy E Stern  3 , Sangita K Jindal  4 , Catherine Racowsky  5 , G David Ball  6
Affiliations

Using the Society for Assisted Reproductive Technology Clinic Outcome System morphological measures to predict live birth after assisted reproductive technology

Barbara Luke et al. Fertil Steril. 2014 Nov.

Abstract

Objective: To model morphological assessments of embryo quality that are predictive of live birth.

Design: Longitudinal cohort using cycles reported in the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) between 2007 and 2011.

Setting: Clinic-based data.

Patient(s): Fresh autologous assisted reproductive technology (ART) cycles with ETs on day 3 or day 5 and morphological assessments reported (25,409 cycles with one embryo transferred and 96,093 cycles with two embryos transferred). Live-birth rates were modeled by morphological assessments using backward-stepping logistic regression for cycle 1 and over five cycles, separately for day 3 and day 5 transfers and number of embryos transferred (1 or 2). Additional models for each day of transfer also included the number of oocytes retrieved and the number of embryos cryopreserved.

Intervention(s): None.

Main outcome measure(s): Live births.

Result(s): Morphological assessments of grade, stage, fragmentation, and symmetry were significant for the day 3 models; grade, stage, and trophectoderm were significant in the day 5 model; inner-cell mass was significant in the models when two embryos were transferred. Number of oocytes retrieved and number of embryos cryopreserved were significant for both day 3 and day 5 models.

Conclusion(s): These findings confirm the significant association between embryo quality parameters reported to SART CORS and live-birth rate after ART.

Keywords: Embryo morphology; embryo fragmentation; embryo symmetry; live birth rate; trophoblast.

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Figures

Figure 1
Figure 1
The effects of grade and stage on live birth rate as a function of age, number of embryos transferred and day of transfer. (a) transfer day 5: grade; (b): day 3: grade; (c) day 5: stage; (d) day 3: stage. 1 and 2 are the number of embryos transferred.
Figure 1
Figure 1
The effects of grade and stage on live birth rate as a function of age, number of embryos transferred and day of transfer. (a) transfer day 5: grade; (b): day 3: grade; (c) day 5: stage; (d) day 3: stage. 1 and 2 are the number of embryos transferred.
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