. 2014 Oct:134:382-9.

doi: 10.1016/j.envres.2014.08.020. Epub 2014 Sep 22.

Polymorphisms in DNA repair genes XRCC1 and XRCC3, occupational exposure to arsenic and sunlight, and the risk of non-melanoma skin cancer in a European case-control study

Affiliations

¹ Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA. Electronic address: ssurdu@albany.edu.
² Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA.
³ Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; New York State Cancer Registry, New York State Department of Health, Albany, NY, USA.
⁵ Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA; Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA.
⁶ Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA; Department of Educational and Counseling Psychology, School of Education, University at Albany, State University of New York, Albany, NY, USA.
⁷ Health Department, Environmental Health Center, Cluj-Napoca, Romania.
⁸ Department of Environmental Epidemiology, National Institute of Environmental Health, Budapest, Hungary.
⁹ Department of Environmental Health, Regional Authority of Public Health, Banska Bystrica, Slovakia.
¹⁰ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
¹¹ Department of Social and Environmental Health Research, Public Health, London School of Hygiene and Tropical Medicine, London, UK; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, UK.
¹² Institut für Chemie-Analytische Chemie, Karl-Franzens-Universität, Graz, Austria.
¹³ Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
¹⁴ Department of Social and Environmental Health Research, Public Health, London School of Hygiene and Tropical Medicine, London, UK.

PMID: 25218703
DOI: 10.1016/j.envres.2014.08.020

Polymorphisms in DNA repair genes XRCC1 and XRCC3, occupational exposure to arsenic and sunlight, and the risk of non-melanoma skin cancer in a European case-control study

Simona Surdu et al. Environ Res. 2014 Oct.

. 2014 Oct:134:382-9.

doi: 10.1016/j.envres.2014.08.020. Epub 2014 Sep 22.

Authors

Affiliations

¹ Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA. Electronic address: ssurdu@albany.edu.
² Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA.
³ Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; New York State Cancer Registry, New York State Department of Health, Albany, NY, USA.
⁵ Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA; Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA.
⁶ Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA; Department of Educational and Counseling Psychology, School of Education, University at Albany, State University of New York, Albany, NY, USA.
⁷ Health Department, Environmental Health Center, Cluj-Napoca, Romania.
⁸ Department of Environmental Epidemiology, National Institute of Environmental Health, Budapest, Hungary.
⁹ Department of Environmental Health, Regional Authority of Public Health, Banska Bystrica, Slovakia.
¹⁰ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
¹¹ Department of Social and Environmental Health Research, Public Health, London School of Hygiene and Tropical Medicine, London, UK; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, UK.
¹² Institut für Chemie-Analytische Chemie, Karl-Franzens-Universität, Graz, Austria.
¹³ Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
¹⁴ Department of Social and Environmental Health Research, Public Health, London School of Hygiene and Tropical Medicine, London, UK.

PMID: 25218703
DOI: 10.1016/j.envres.2014.08.020

Abstract

X-ray repair cross-complementing group 1 (XRCC1) and group 3 (XRCC3) polymorphisms are relatively frequent in Caucasian populations and may have implications in skin cancer modulation. A few studies have evaluated their association with non-melanoma skin cancer (NMSC), but the results are inconsistent. In the current study, we aim to assess the impact of XRCC1 R399Q and XRCC3 T241M polymorphisms on the risk of NMSC associated with sunlight and arsenic exposure. Study participants consist of 618 new cases of NMSC and 527 hospital-based controls frequency matched on age, sex, and county of residence from Hungary, Romania, and Slovakia. Adjusted effects are estimated using multivariable logistic regression. The results indicate an increased risk of squamous cell carcinoma (SCC) for the homozygous variant genotype of XRCC1 R399Q (OR 2.53, 95% CI 1.14-5.65) and a protective effect against basal cell carcinoma (BCC) for the homozygous variant genotype of XRCC3 T241M (OR 0.61, 95% CI 0.41-0.92), compared with the respective homozygous common genotypes. Significant interactions are detected between XRCC3 T241M and sunlight exposure at work, and between XRCC3 T241M and exposure to arsenic in drinking water (p-value for interaction <0.10). In conclusion, the current study demonstrates that polymorphisms in XRCC genes may modify the associations between skin cancer risk and exposure to sunlight or arsenic. Given the high prevalence of genetic polymorphisms modifying the association between exposure to environmental carcinogens and NMSC, these results are of substantial relevance to public health.

Keywords: Arsenic; DNA repair polymorphisms; Exposure; Non-melanoma skin cancer; Sunlight.

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Polymorphisms in DNA repair genes XRCC1 and XRCC3, occupational exposure to arsenic and sunlight, and the risk of non-melanoma skin cancer in a European case-control study

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Polymorphisms in DNA repair genes XRCC1 and XRCC3, occupational exposure to arsenic and sunlight, and the risk of non-melanoma skin cancer in a European case-control study

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