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Comment
. 2014 Oct;134(10):2488-2491.
doi: 10.1038/jid.2014.245.

Metformin: a potential drug to treat hyperpigmentation disorders

Elisabeth S Belisle  1 , Hee-Young Park  2
Affiliations
Free article
Comment

Metformin: a potential drug to treat hyperpigmentation disorders

Elisabeth S Belisle et al. J Invest Dermatol. 2014 Oct.
Free article

Abstract

Hyperpigmentation disorders are generally difficult to treat because of the limited availability of effective therapeutics with minimal side effects. In this issue, Lehraiki et al. report that metformin, an antidiabetic drug, inhibited melanogenesis, in vitro and in vivo, and they suggest that metformin may be used to treat hyperpigmentation disorders. This commentary reviews the molecular mechanisms through which metformin inhibits melanogenesis and examines metformin as a potential drug to treat hyperpigmentation.

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Comment on

  • Inhibition of melanogenesis by the antidiabetic metformin.
    Lehraiki A, Abbe P, Cerezo M, Rouaud F, Regazzetti C, Chignon-Sicard B, Passeron T, Bertolotto C, Ballotti R, Rocchi S. Lehraiki A, et al. J Invest Dermatol. 2014 Oct;134(10):2589-2597. doi: 10.1038/jid.2014.202. Epub 2014 Apr 22. J Invest Dermatol. 2014. PMID: 24756109

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