Cells of origin in skin cancer
- PMID: 25219650
- DOI: 10.1038/jid.2014.233
Cells of origin in skin cancer
Abstract
Adult skin stem cells do not protect their genome by asymmetric chromosome segregation; thus, they are prone to accumulating oncogenic mutations.
Comment on
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DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.J Invest Dermatol. 2014 Oct;134(10):2620-2629. doi: 10.1038/jid.2014.157. Epub 2014 Mar 24. J Invest Dermatol. 2014. PMID: 24662765
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