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Comment
. 2014 Oct;134(10):2493-2496.
doi: 10.1038/jid.2014.244.

Epidermal, sebaceous, and melanocytic nevoid proliferations are spectrums of mosaic RASopathies

Su Luo  1 , Hensin Tsao  2
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Free article
Comment

Epidermal, sebaceous, and melanocytic nevoid proliferations are spectrums of mosaic RASopathies

Su Luo et al. J Invest Dermatol. 2014 Oct.
Free article

Abstract

Growing evidence demonstrates that various nevoid proliferations such as keratinocytic epidermal nevi and nevus sebaceous result from somatic mosaicism. Many of the mutations identified have been within the RAF/RAS/MAPK pathway, hence supporting the previously introduced term "mosaic RASopathy" for these nevi. In this issue, Kinsler et al. were among the first to characterize certain pigmented melanocytic nevi that may also fit this paradigm. To better frame these findings, we provide a summary of the analogous genotypic profiles for epidermal and melanocytic nevi from recent studies.

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References

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