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Review
. 2014 Nov;24(8):319-24.
doi: 10.1016/j.tcm.2014.08.001. Epub 2014 Aug 7.

Adiponectin and insulin cross talk: the microvascular connection

Lina Zhao  1 , Zhuo Fu  1 , Zhenqi Liu  2
Affiliations
Review

Adiponectin and insulin cross talk: the microvascular connection

Lina Zhao et al. Trends Cardiovasc Med. 2014 Nov.

Abstract

Adiponectin exerts both vasodilatory and insulin-sensitizing actions and its levels are decreased in insulin-resistant humans and animals. The mechanisms underlying adiponectin׳s insulin-sensitizing effect have been extensively investigated but remain largely unclear. Muscle microvasculature critically regulates muscle insulin action by modulating insulin delivery to the microvessels nurturing the muscle cells and the trans-endothelial insulin transport. We have recently reported that adiponectin exerts its insulin-sensitizing effect via recruiting muscle microvasculature, expanding the endothelial surface area, and increasing insulin delivery to and thus action in muscle. The current review focuses on the microvascular connection between the adiponectin and insulin cross talk.

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Figures

Figure
Figure
Schematic diagram of adiponectin’s effects on microvascular recruitment and insulin delivery in muscle.
See this image and copyright information in PMC

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