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Clinical Trial
. 1989 Mar-Jun;16(2-3):115-20.
doi: 10.1016/0165-0327(89)90064-5.

Sulpiride treatment of acute mania with a comparison of the effects on plasma hormone concentrations of lithium and sulpiride treatment

J E Christie  1 , L J Whalley, R Hunter, J Bennie, G Fink
Affiliations
Clinical Trial

Sulpiride treatment of acute mania with a comparison of the effects on plasma hormone concentrations of lithium and sulpiride treatment

J E Christie et al. J Affect Disord. 1989 Mar-Jun.

Abstract

Sulpiride, in this open study of acute manic patients, had a clear antimanic action with all eight patients responding to sulpiride treatment without the need for other antipsychotic drugs. Plasma prolactin concentrations were increased and oestrogen-stimulated neurophysin concentrations decreased by sulpiride but were unchanged by lithium treatment, whereas TSH concentrations showed a rapid increase following the introduction of lithium therapy.

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