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. 2014 Jul 1;9(13):1265-6.
doi: 10.4103/1673-5374.137572.

Beyond taxol: microtubule-based strategies for promoting nerve regeneration after injury

Peter W Baas  1
Affiliations

Beyond taxol: microtubule-based strategies for promoting nerve regeneration after injury

Peter W Baas. Neural Regen Res. .
No abstract available

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Figures

Figure 1
Figure 1
Microtubule-severing proteins have very different effects on microtubules, depending on the preference of the particular severing protein for stable or labile domains of microtubules. Microtubules in the axon consist of a stable domain toward the minus end of the microtubule and a labile domain toward the plus end. Shown in the figure are microtubules with stable and labile domains indicated in red and yellow respectively. Severing proteins are shown as scissors. Severing in the stable domain would increase microtubule number, while severing in the labile domain would pare down the labile domain without creating more microtubules. Katanin and spastin preferentially sever stable domains whereas we posit that fidgetins preferentially sever labile domains. Figure prepared by Andrew Matamoros.
Figure 2
Figure 2
Fidgetin, a potential regulator of labile microtubule mass in the axon, may be a powerful target for therapeutic intervention to augment regeneration of injured adult axons. If this hypothesis is correct, suppressing fidgetins would result in an expansion of labile microtubule domains, which we posit should be conducive to axonal regeneration. Shown in the figure are microtubules with stable and labile domains indicated in red and yellow respectively, with fidgetin shown as scissors. In the figure, for clarity of the hypothesis, the microtubules are shown with stable and labile domains aligned, but in actual fact, the microtubules are staggered along the length of the axon, so that stable and labile domains are not in alignment. Figure prepared by Andrew Matamoros.
See this image and copyright information in PMC

References

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