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. 2014 Sep 1;8(9):1121-1133.
doi: 10.1016/j.rasd.2014.05.006.

Aggressive Behavior Problems in Children with Autism Spectrum Disorders: Prevalence and Correlates in a Large Clinical Sample

Alison Presmanes Hill  1 , Katharine E Zuckerman  2 , Arlene D Hagen  3 , Daniel J Kriz  4 , Susanne W Duvall  4 , Jan van Santen  1 , Joel Nigg  5 , Damien Fair  6 , Eric Fombonne  7
Affiliations

Aggressive Behavior Problems in Children with Autism Spectrum Disorders: Prevalence and Correlates in a Large Clinical Sample

Alison Presmanes Hill et al. Res Autism Spectr Disord. .

Abstract

Aggressive behavior problems (ABP) are frequent yet poorly understood in children with Autism Spectrum Disorders (ASD) and are likely to co-vary significantly with comorbid problems. We examined the prevalence and sociodemographic correlates of ABP in a clinical sample of children with ASD (N = 400; 2-16.9 years). We also investigated whether children with ABP experience more intensive medical interventions, greater impairments in behavioral functioning, and more severe comorbid problems than children with ASD who do not have ABP. One in four children with ASD had Child Behavior Checklist scores on the Aggressive Behavior scale in the clinical range (T-scores ≥ 70). Sociodemographic factors (age, gender, parent education, race, ethnicity) were unrelated to ABP status. The presence of ABP was significantly associated with increased use of psychotropic drugs and melatonin, lower cognitive functioning, lower ASD severity, and greater comorbid sleep, internalizing, and attention problems. In multivariate models, sleep, internalizing, and attention problems were most strongly associated with ABP. These comorbid problems may hold promise as targets for treatment to decrease aggressive behavior and proactively identify high-risk profiles for prevention.

Keywords: aggression; attention problems; autism spectrum disorders; internalizing problems; psychotropic drugs; sleep.

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Figures

Figure 1
Figure 1
Histogram of CBCL Aggressive Behavior T-scores with kernel density plot overlaid (in gray).
Figure 2
Figure 2
Proportion of children with ABP by age with 95% confidence intervals.
See this image and copyright information in PMC

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