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Comparative Study
. 2014 Sep 15;9(9):e106591.
doi: 10.1371/journal.pone.0106591. eCollection 2014.

Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis

Markus Wettstein  1 , Lorenz Radlinger  2 , Thomas Riedel  3
Affiliations
Comparative Study

Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis

Markus Wettstein et al. PLoS One. .

Abstract

Background and objectives: We investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF).

Methods: In 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous breathing, continuous positive airway pressure (CPAP) and positive expiratory pressure (PEP) therapy randomly applied in upright and lateral position. Spatial and temporal ventilation distribution was assessed.

Results: The proportion of ventilation directed to the dependent lung significantly increased in lateral position compared to upright in healthy and CF. This effect was enhanced with CPAP but neutralised with PEP, whereas the effect of PEP was larger in the healthy group. Temporal ventilation distribution showed exactly the opposite with homogenisation during CPAP and increased inhomogeneity with PEP.

Conclusions: PEP shows distinct differences to CPAP with respect to its impact on ventilation distribution in healthy adults and CF subjects EIT might be used to individualise respiratory physiotherapy.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Spatial ventilation distribution with different breathing aids.
Mean (95% CI) of the percentage of ventilation directed to the right lung in right lateral position for healthy and CF. For comparison spontaneous breathing in upright position is shown. Values >0.5 indicate more ventilation of the right lung, values <0.5 more ventilation of the left lung.
See this image and copyright information in PMC

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