Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014 Sep 15:7:648.
doi: 10.1186/1756-0500-7-648.

1-day bowel preparation with polyethylene glycol 3350 is as effective and safe as a 3-day preparation for colonoscopy in children

Serge A Sorser  1 , Venkata Konanki, Alice Hursh, Karen Hagglund, Hernando Lyons
Affiliations
Randomized Controlled Trial

1-day bowel preparation with polyethylene glycol 3350 is as effective and safe as a 3-day preparation for colonoscopy in children

Serge A Sorser et al. BMC Res Notes. .

Abstract

Background: Polyethylene Glycol 3350 (Miralax®) without electrolytes is commonly used for 3-4 days as bowel preparation for colonoscopy in children. One-day preparation has been anecdotally reported to be effective but there are few published prospective studies comparing the safety and efficacy of one-day preparation with that of three-day preparation. This study was conducted to compare the efficacy and safety of a one-day bowel preparation with Miralax® with that of a three-day preparation for colonoscopy in children.

Methods: We conducted a prospective, randomized controlled trial with children age 2-21 yrs. undergoing elective colonoscopy. Patients were randomly assigned to receive Miralax® for either one or three days. Children with known electrolyte disturbances, dehydration, fecal impaction, metabolic or renal disease were excluded. A metabolic panel was monitored before and after bowel preparation. Subjects reported the tolerability and side effects of Miralax® via a survey. Effectiveness of the bowel preparation was assessed using a stool diary and a bowel cleansing scale during colonoscopy.

Results: 32 subjects were enrolled; 18 received one-day bowel preparation and 14 received 3-day preparation. There were no differences between the groups in efficacy of bowel preparation based on colonoscopic grading or the safety of the preparation. One-day preparation was as well tolerated as three-day preparation.

Conclusion: Miralax® used one day as bowel preparation for elective colonoscopy in children is safe, effective and well tolerated. Physicians should consider offering a one-day option for bowel preparation, which would allow children to miss fewer days of school prior to colonoscopy.

Trial registration number: NCT02174497. Date of Registration: 02 May, 2014 URL of register: clinicaltrials.gov.

PubMed Disclaimer

References

    1. Hassall E, Barclay GN, Ament ME. Colonoscopy in childhood. Pediatrics. 1984;73(5):594–9. - PubMed
    1. Sasaki H, Yagucji T, Hasegawa K, Lee B, Noguchi T, Nagasako K. Pediatric colonoscopy. Dis Colon Rectum. 1981;24(4):257–8. doi: 10.1007/BF02641871. - DOI - PubMed
    1. Fox VL. Pediatric endoscopy. Gastrointest Endosc Clin N Am. 2000;10(1):175–94. - PubMed
    1. Wyllie R, Kay MH. Colonoscopy and therapeutic intervention in infants and children. Gastrointest Endosc Clin N Am. 1994;4(1):143–60. - PubMed
    1. Panshankar DS, Uc A, Bishop WP. Polyethylene glycol 3350 without electrolytes: a new, safe, effective, and palatable bowel preparation for colonoscopy in children. J Pediatr. 2004;144(3):358–62. doi: 10.1016/j.jpeds.2003.11.033. - DOI - PubMed

Publication types

Associated data

LinkOut - more resources