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Editorial
. 2014 Dec;64(6):1192-3.
doi: 10.1161/HYPERTENSIONAHA.114.04348. Epub 2014 Sep 15.

Endothelial dysfunction potentially interacts with impaired glucose metabolism to increase cardiovascular risk

Guanghong Jia  1 , James R Sowers  2
Affiliations
Editorial

Endothelial dysfunction potentially interacts with impaired glucose metabolism to increase cardiovascular risk

Guanghong Jia et al. Hypertension. 2014 Dec.
No abstract available

Keywords: cardiovascular disease; population; type 2 diabetes mellitus.

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Conflict of interest statement

Disclosure

No potential conflicts of interest relevant to this article were report.

Figures

Figure 1
Figure 1
Proposed molecular mechanism for insulin resistance in endothelial dysfunction. Abbreviation: JNK, c-Jun N-terminal kinase; IKKβ, IκB kinase; PKC, protein kinase C; mTOR, mammalian target of rapamycin; S6K, ribosomal S6 kinases; MAPK, mitogen-activated protein kinase; PI3-K/Akt, phosphatidylinositide 3-kinases/protein kinase B; ET-1, endothelin-1; NO, nitric oxide; eNOS, endothelial NO synthase. IRS-1/2, insulin receptor substrate 1/2;
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References

    1. DREAM Trial Investigators. Bosch J, Yusuf S, Gerstein HC, Pogue J, Sheridan P, Dagenais G, Diaz R, Avezum A, Lanas F, Probstfield J, Fodor G, Holman RR. Effect of ramipril on the incidence of diabetes. N Engl J Med. 2006;355:1551–1562. - PubMed
    1. Sowers JR. Diabetes mellitus and vascular disease. Hypertension. 2013;61:943–947. - PMC - PubMed
    1. Frankel DS, Meigs JB, Massaro JM, Wilson PW, O'Donnell CJ, D'Agostino RB, Tofler GH. Von Willebrand factor, type 2 diabetes mellitus, and risk of cardiovascular disease: the framingham offspring study. Circulation. 2008;118:2533–2539. - PMC - PubMed
    1. Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, Liu S. Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women. Diabetes. 2007;56:1898–1904. - PMC - PubMed
    1. Kim JA, Jang HJ, Martinez-Lemus LA, Sowers JR. Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation. Am J Physiol Endocrinol Metab. 2012;15(302):E201–E208. - PMC - PubMed

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