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. 2014 Sep;30(5):1113-8.
doi: 10.12669/pjms.305.5080.

Evaluation of risk factors for development of severe hyperbilirubinemia in term and near term infants in Turkey

Ali Bulbul  1 , Nihal Cayonu  2 , Merve Emecen Sanli  3 , Sinan Uslu  4
Affiliations

Evaluation of risk factors for development of severe hyperbilirubinemia in term and near term infants in Turkey

Ali Bulbul et al. Pak J Med Sci. 2014 Sep.

Abstract

Objective: To determine clinical features, etiology and risk factors in term and near term newborns with severe hyperbilirubinemia.

Methods: During ten years period (2000 - 2009), infants of ≥ 35 gestational weeks who received phototherapy were evaluated retrospectively. The study population was divided into two groups and clinical features, etiology and risk factors were compared. Group 1 defined by those who had bilirubin level ≥25 mg/dl (severe hyperbilirubinemia) and group 2 defined by bilirubin level <25 mg/dl.

Results: During the study period 1335 babies were evaluated. Severe hyperbilirubinemia was found in 137 (10.3%) patients. Total serum bilirubin level was 29.7±4.7 mg/dl in group 1 and 18.9±3.5 mg/dl in group 2. Pathological weight loss, vaginal delivery and supplementary feeding were identified as significant risk factors for development of severe hyperbilirubinemia (p <0.001, p <0.001 and p = 0.04, respectively). The time at recognition of jaundice by family and postnatal age at admission were significantly higher in group 1. The ratios of previous sibling received phototherapy and being the second child or after were found higher in group 1.

Conclusion: Pathological weight loss, vaginal delivery and supplementary feeding were determined as risk factors for development of severe hyperbilirubinemia. The newborns with severe hyperbilirubinemia had late recognition of jaundice and admission to hospital by their families.

Keywords: Feeding; Hyperbilirubinemia; Newborn; Risk factors.

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References

    1. Liu S, Wen SW, McMillan D, Trouton K, Fowler D, McCourt C. Increased neonatal readmission rate associated with decreased length of hospital stay at birth in Canada. Can J Public Health. 2000;91(1):46–50. - PMC - PubMed
    1. Brown AK, Damus K, Kim MH, King K, Harper R, Campbell D, et al. Factors relating to readmission of term and near-term neonates in the first two weeks of life. Early Discharge Survey Group of the Health Professional Advisory Board of the Greater New York Chapter of the March of Dimes. J Perinat Med. 1999;27(4):263–275. doi:10.1515/JPM.1999.037. - PubMed
    1. Bulbul A, Okan F, Uslu S, Isci E, Nuhoglu A. Clinical characteristics of term newborns with hiperbilirubinemia and identification of the risk factors for hiperbilirubinemia. Turk Arch Ped. 2005;40:204–210.
    1. Bulbul A, Okan F, Kabakoglu Unsur E, Nuhoglu A. Adverse events associated with exchange transfusion and etiology of severe hyperbilirubinemia in near-term and term newborns. Turk J Med Sci. 2011;41(1):93–100. doi:10.3906/sag-0911-395.
    1. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297–316. doi: 10.1542/peds.114.1.297. - PubMed

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