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. 2014;5(3):175-81.
doi: 10.5847/wjem.j.issn.1920-8642.2014.03.003.

Domestic versus imported drug-eluting stents for the treatment of patients with acute coronary syndrome

Hai-Mu Yao  1 , Tong-Wen Sun  2 , You-Dong Wan  2 , Xiao-Juan Zhang  2 , Xin Fu  1 , De-Liang Shen  1 , Jin-Ying Zhang  1 , Ling Li  1
Affiliations

Domestic versus imported drug-eluting stents for the treatment of patients with acute coronary syndrome

Hai-Mu Yao et al. World J Emerg Med. 2014.

Abstract

Background: The application of coronary stents, especially drug-eluting stents (DESs), has made percutaneous coronary intervention (PCI) one of important therapeutic methods for CHD. DES has reduced the in-stent restenosis to 5%-9% and significantly improved the long-term prognosis of patients with CHD. The study aimed to investigate the long-term efficacy and safety of domestic drug-eluting stents (DESs) in patients with acute coronary syndrome (ACS).

Methods: All patients with ACS who had undergone successful percutaneous coronary intervention (PCI) in the First Affiliated Hospital of Zhengzhou University from July 2009 to December 2010 were included in this study. Patients were excluded from the study if they were implanted with bare metal stents or different stents (domestic and imported DESs) simultaneously. The included patients were divided into two groups according to different stents implanted: domestic DESs and imported DESs.

Results: In the 1 683 patients of this study, 1 558 (92.6%) patients were followed up successfully for an average of (29.1±5.9) months. 130 (8.3%) patients had major adverse cardiovascular events (MACEs), including cardiac death in 32 (2.1%) patients, recurrent myocardial infarction in 16 (1%), and revascularization in 94 (6%). The rates of cardiac death, recurrent myocardial infarction, revascularization, in-stent restenosis, stent thrombosis and other MACEs were not significantly different between the two groups (all P>0.05). Multivarite logistic regression revealed that diabetes mellitus (OR=1.75, 95%CI: 1.09-2.82, P=0.021), vascular numbers of PCI (OR=2.16, 95%CI: 1.22-3.83, P=0.09) and PCI with left main lesion (OR=9.47, 95%CI: 2.96-30.26, P=0.01) were independent prognostic factors of MACEs. The Kaplan-Meier method revealed that there was no significant difference in cumulative survival rates and survival rates free from clinical events between the two groups (all P>0.05).

Conclusions: The incidences of clinical events and cumulative survival rates are not statistically different between domestic DESs and imported DESs. Domestic DES is effective and safe in the treatment of patients with ACS.

Keywords: Acute coronary syndrome; Cardiovascular adverse events; Drug-eluting stent; Percutaneous coronary intervention.

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Conflict of interest statement

Conflicts of interest: We have no conflicts of interest to this report.

Figures

Figure 1
Figure 1
The cumulative survival rates of the two groups.
Figure 2
Figure 2
The cumulative survival rates free from clinical events of the two groups.
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References

    1. Ge J, Qian J, Wang X, Wang Q, Yan W, Yan Y, et al. Effectiveness and safety of the sirolimus-eluting stents coated with bioabsorbable polymer coating in human coronary arteries. Catheter Cardiovasc Interv. 2007;69:198–202. - PubMed
    1. Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O’shaughnessy C, et al. Sirolimus -eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 2003;349:1315–1323. - PubMed
    1. Park KW, Kang SH, Park KH, Choi DH, Lee HY, Kang HJ, et al. Sirolimus- vs paclitaxel-eluting stents for the treatment of unprotected left main coronary artery stenosis: Complete 2-year follow-up of a two-center registry. Int J Cardiol. 2011;151:89–95. - PubMed
    1. Zahn R, Neumann FJ, Büttner HJ, Richardt G, Schneider S, Levenson B, et al. Long-term follow-up after coronary stenting with the sirolimus eluting stent in clinical practice: results from the prospective multi-center German Cypher Stent Registry. Clin Res Cardiol. 2012;10:709–716. - PubMed
    1. Ogita M, Miyauchi K, Dohi T, Wada H, Tuboi S, Miyazaki T, et al. Gender-based outcomes among patients with diabetes mellitus after percutaneous coronary intervention in drug-eluting stent era. Int Heart J. 2011;52:348–352. - PubMed

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