. 2014 Sep 16;9(9):e107181.

doi: 10.1371/journal.pone.0107181. eCollection 2014.

Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China

Jianfang Zhou¹, Chuanyun Qian², Mingyan Zhao³, Xiangyou Yu⁴, Yan Kang⁵, Xiaochun Ma⁶, Yuhang Ai⁷, Yuan Xu⁸, Dexin Liu⁹, Youzhong An¹⁰, Dawei Wu¹¹, Renhua Sun¹², Shusheng Li¹³, Zhenjie Hu¹⁴, Xiangyuan Cao¹⁵, Fachun Zhou¹⁶, Li Jiang¹⁷, Jiandong Lin¹⁸, Enqiang Mao¹⁹, Tiehe Qin²⁰, Zhenyang He²¹, Lihua Zhou²², Bin Du¹; China Critical Care Clinical Trials Group

Collaborators, Affiliations

Collaborators

China Critical Care Clinical Trials Group:
Bin Du, Li Weng, Chuanyun Qian, Wei Zhang, Mingyan Zhao, Dongsheng Fei, Xiangyou Yu, Yi Wang, Yan Kang, Xuelian Liao, Xiaochun Ma, Yini Sun, Yuhang Ai, Li Huang, Yuan Xu, Wei He, Yongjie Yin, Dexin Liu, Huiying Zhao, Dawei Wu, Chen Li, Renhua Sun, Qian Li, Shusheng Li, Xiao Ran, Zhenjie Hu, Yan Huo, Xiangyuan Cao, Xigang Ma, Fachun Zhou, Fang Xu, Li Jiang, Qi Zhang, Jiandong Lin, Xiongjian Xiao, Enqiang Mao, Cheng Zhu, Tiehe Qin, Shouhong Wang, Zhenyang He, Rui Li, Lihua Zhou, Lipeng Zhang, Rongqing Sun, Yuexia Li, Xijing Zhang, Binxiao Su

Affiliations

¹ Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
² Department of Emergency Medicine and Medical ICU, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
³ Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
⁴ Department of Critical Care Medicine, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
⁵ Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
⁶ Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
⁷ Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China.
⁸ Department of Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
⁹ Department of Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China.
¹⁰ Department of Critical Care Medicine, Peking University People's Hospital, Beijing, China.
¹¹ Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China.
¹² Department of Critical Care Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China.
¹³ Department of Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
¹⁴ Department of Critical Care Medicine, Hebei Medical University Fourth Hospital, Shijiazhuang, China.
¹⁵ Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, China.
¹⁶ Department of Emergency and Intensive Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
¹⁷ Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, Beijing, China.
¹⁸ Department of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
¹⁹ Emergency ICU, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
²⁰ Department of Critical Care Medicine, Guangdong General Hospital, Guangzhou, China.
²¹ Department of Critical Care Medicine, Hainan Provincial People's Hospital, Haikou, China.
²² Department of Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China.

PMID: 25226033
PMCID: PMC4167333
DOI: 10.1371/journal.pone.0107181

Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China

Jianfang Zhou et al. PLoS One. 2014.

. 2014 Sep 16;9(9):e107181.

doi: 10.1371/journal.pone.0107181. eCollection 2014.

Authors

Collaborators

China Critical Care Clinical Trials Group:
Bin Du, Li Weng, Chuanyun Qian, Wei Zhang, Mingyan Zhao, Dongsheng Fei, Xiangyou Yu, Yi Wang, Yan Kang, Xuelian Liao, Xiaochun Ma, Yini Sun, Yuhang Ai, Li Huang, Yuan Xu, Wei He, Yongjie Yin, Dexin Liu, Huiying Zhao, Dawei Wu, Chen Li, Renhua Sun, Qian Li, Shusheng Li, Xiao Ran, Zhenjie Hu, Yan Huo, Xiangyuan Cao, Xigang Ma, Fachun Zhou, Fang Xu, Li Jiang, Qi Zhang, Jiandong Lin, Xiongjian Xiao, Enqiang Mao, Cheng Zhu, Tiehe Qin, Shouhong Wang, Zhenyang He, Rui Li, Lihua Zhou, Lipeng Zhang, Rongqing Sun, Yuexia Li, Xijing Zhang, Binxiao Su

Affiliations

¹ Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
² Department of Emergency Medicine and Medical ICU, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
³ Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
⁴ Department of Critical Care Medicine, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
⁵ Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
⁶ Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
⁷ Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China.
⁸ Department of Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
⁹ Department of Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China.
¹⁰ Department of Critical Care Medicine, Peking University People's Hospital, Beijing, China.
¹¹ Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China.
¹² Department of Critical Care Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China.
¹³ Department of Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
¹⁴ Department of Critical Care Medicine, Hebei Medical University Fourth Hospital, Shijiazhuang, China.
¹⁵ Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, China.
¹⁶ Department of Emergency and Intensive Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
¹⁷ Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, Beijing, China.
¹⁸ Department of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
¹⁹ Emergency ICU, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
²⁰ Department of Critical Care Medicine, Guangdong General Hospital, Guangzhou, China.
²¹ Department of Critical Care Medicine, Hainan Provincial People's Hospital, Haikou, China.
²² Department of Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China.

PMID: 25226033
PMCID: PMC4167333
DOI: 10.1371/journal.pone.0107181

Abstract

Introduction: Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology and outcome of severe sepsis and septic shock in mixed ICU in mainland China, as well as the independent predictors of mortality.

Methods: We performed a 2-month prospective, observational cohort study in 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during the study period were screened and patients with severe sepsis or septic shock were included.

Results: A total of 484 patients, 37.3 per 100 ICU admissions were diagnosed with severe sepsis (n = 365) or septic shock (n = 119) according to clinical criteria and included into this study. The most frequent sites of infection were the lung and abdomen. The overall ICU and hospital mortality rates were 28.7% (n = 139) and 33.5% (n = 162), respectively. In multivariate analyses, APACHE II score (odds ratio[OR], 1.068; 95% confidential interval[CI], 1.027-1.109), presence of ARDS (OR, 2.676; 95%CI, 1.691-4.235), bloodstream infection (OR, 2.520; 95%CI, 1.142-5.564) and comorbidity of cancer (OR, 2.246; 95%CI, 1.141-4.420) were significantly associated with mortality.

Conclusions: Our results indicated that severe sepsis and septic shock were common complications in ICU patients and with high mortality in China, and can be of help to know more about severe sepsis and septic shock in China and to improve characterization and risk stratification in these patients.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

**Figure 1. Flow diagram of enrolled patients and their outcome.**
ICU, intensive care unit; LOS, length of stay.

See this image and copyright information in PMC

References

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Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China

Collaborators

Affiliations

Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical