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Comment
. 2014 Sep 30;111(39):14009-10.
doi: 10.1073/pnas.1415576111. Epub 2014 Sep 16.

Not so sweet malignant transformation

Jacques U Baenziger  1
Affiliations
Comment

Not so sweet malignant transformation

Jacques U Baenziger. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Tn antigen arises by truncation of mucin-type O-glycans. Synthesis of mucin-type O-glycans is initiated by the transfer of GalNAc from UDP-GalNAc to Ser or Thr residues by one or more of 20 known peptide-specific GalNAc-transferases. In most instances Gal is transferred from UDP-Gal to the GalNAc by C1GalT1. Other sugars and branch points can then be added by a series of additional glycosyltransferases to form a variety of structures. The private chaperone COSMC is essential for expression of active C1GalT1. In the absence of COSMC no C1GalT1 activity is expressed and the O-linked GalNAc is not further modified and remains “truncated.” Although GalNAc-Ser/Thr is the essential feature of Tn antigens, the peptide surrounding the GalNAc-Ser/Thr is also a part of the epitope. As a consequence, antibodies can be raised that distinguish Tn antigen on peptide A from Tn antigen on peptide B.
See this image and copyright information in PMC

Comment on

  • Immature truncated O-glycophenotype of cancer directly induces oncogenic features.
    Radhakrishnan P, Dabelsteen S, Madsen FB, Francavilla C, Kopp KL, Steentoft C, Vakhrushev SY, Olsen JV, Hansen L, Bennett EP, Woetmann A, Yin G, Chen L, Song H, Bak M, Hlady RA, Peters SL, Opavsky R, Thode C, Qvortrup K, Schjoldager KT, Clausen H, Hollingsworth MA, Wandall HH. Radhakrishnan P, et al. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4066-75. doi: 10.1073/pnas.1406619111. Epub 2014 Aug 12. Proc Natl Acad Sci U S A. 2014. PMID: 25118277 Free PMC article.

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