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Comment
. 2014 Sep 30;111(39):14015-6.
doi: 10.1073/pnas.1416560111. Epub 2014 Sep 16.

Arginine deprivation and autophagic cell death in cancer

Peter Wojciech Szlosarek  1
Affiliations
Comment

Arginine deprivation and autophagic cell death in cancer

Peter Wojciech Szlosarek. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Biphasic autophagic response following arginine deprivation in ASS1-ve tumor cells: prosurvival phase followed by excessive autophagy leading to cell death. A, autophagosome; AL, autolysosome; CAT, cationic amino acid transporter; GA, giant autophagosome; L, lysosome; M, mitochondrion; N, nucleus. ASS1-ve tumor cells are sensitive to the arginine-depletor ADI-PEG20 and exhibit caspase-dependent or -independent apoptosis associated with DNA leakage.
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