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Review
. 2014 Aug 26;6(8):861-4.
doi: 10.4330/wjc.v6.i8.861.

Long term negative pressure ventilation: Rescue for the failing fontan?

Shriprasad R Deshpande  1 , Kevin O Maher  1
Affiliations
Review

Long term negative pressure ventilation: Rescue for the failing fontan?

Shriprasad R Deshpande et al. World J Cardiol. .

Abstract

Current treatment strategies for single ventricle patients include non-intervention strategy, surgical palliation or primary transplantation. Surgical palliation includes a staged operative course culminating in the Fontan operation. With progress in surgical techniques, the survival has been improving. However, almost all of these Fontan patients will demonstrate pathophysiologic changes that ultimately constitute "Fontan failure physiology". This article reviews the pathophysiologic changes, current approach to management of these patients and proposes a novel way of reversing some of the pathophysiologic changes by utilization of negative pressure ventilation.

Keywords: Cardiorespiratory interactions; Congenital heart disease; Fontan; Negative pressure ventilation; Single ventricle physiology.

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