Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Oct 8;136(40):14314-9.
doi: 10.1021/ja5093612. Epub 2014 Sep 29.

Direct catalytic N-alkylation of amines with carboxylic acids

Iván Sorribes  1 , Kathrin Junge, Matthias Beller
Affiliations

Direct catalytic N-alkylation of amines with carboxylic acids

Iván Sorribes et al. J Am Chem Soc. .

Erratum in

Abstract

A straightforward process for the N-alkylation of amines has been developed applying readily available carboxylic acids and silanes as the hydride source. Complementary to known reductive aminations, effective C-N bond construction proceeds under mild conditions and allows obtaining a broad range of alkylated secondary and tertiary amines, including fluoroalkyl-substituted anilines as well as the bioactive compound Cinacalcet HCl.

PubMed Disclaimer

Publication types

LinkOut - more resources