GATM locus does not replicate in rhabdomyolysis study

James S Floyd¹, Joshua C Bis¹, Jennifer A Brody¹, Susan R Heckbert², Kenneth Rice³, Bruce M Psaty⁴

Affiliations

¹ 1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356420, Seattle, Washington 98195-6420, USA.
² 1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Epidemiology, University of Washington, 1959 Northeast Pacific Street, Box 357236, Seattle, Washington 98195-7236, USA [3] Group Health Research Institute, Group Health Cooperative, 1730 Minor Avenue, Suite 1600, Seattle, Washington 98101-1448, USA.
³ 1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Biostatistics, University of Washington, 1959 Northeast Pacific Street, Box 357232, Seattle, Washington 98195-7323, USA.
⁴ 1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356420, Seattle, Washington 98195-6420, USA [3] Department of Epidemiology, University of Washington, 1959 Northeast Pacific Street, Box 357236, Seattle, Washington 98195-7236, USA [4] Group Health Research Institute, Group Health Cooperative, 1730 Minor Avenue, Suite 1600, Seattle, Washington 98101-1448, USA.

PMID: 25230668
PMCID: PMC4230441
DOI: 10.1038/nature13629

Comment

GATM locus does not replicate in rhabdomyolysis study

James S Floyd et al. Nature. 2014.

. 2014 Sep 18;513(7518):E1-3.

doi: 10.1038/nature13629.

Authors

James S Floyd¹, Joshua C Bis¹, Jennifer A Brody¹, Susan R Heckbert², Kenneth Rice³, Bruce M Psaty⁴

Affiliations

¹ 1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356420, Seattle, Washington 98195-6420, USA.
² 1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Epidemiology, University of Washington, 1959 Northeast Pacific Street, Box 357236, Seattle, Washington 98195-7236, USA [3] Group Health Research Institute, Group Health Cooperative, 1730 Minor Avenue, Suite 1600, Seattle, Washington 98101-1448, USA.
³ 1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Biostatistics, University of Washington, 1959 Northeast Pacific Street, Box 357232, Seattle, Washington 98195-7323, USA.
⁴ 1] Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356420, Seattle, Washington 98195-6420, USA [3] Department of Epidemiology, University of Washington, 1959 Northeast Pacific Street, Box 357236, Seattle, Washington 98195-7236, USA [4] Group Health Research Institute, Group Health Cooperative, 1730 Minor Avenue, Suite 1600, Seattle, Washington 98101-1448, USA.

PMID: 25230668
PMCID: PMC4230441
DOI: 10.1038/nature13629

No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing financial interests: BMP serves on the DSMB for a clinical trial of a device funded by the manufacturer (Zoll LifeCor).

Comment in

Mangravite et al. reply.
Mangravite LM, Engelhardt BE, Stephens M, Krauss RM. Mangravite LM, et al. Nature. 2014 Sep 18;513(7518):E3. doi: 10.1038/nature13630. Nature. 2014. PMID: 25230670 No abstract available.

Comment on

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy.
Mangravite LM, Engelhardt BE, Medina MW, Smith JD, Brown CD, Chasman DI, Mecham BH, Howie B, Shim H, Naidoo D, Feng Q, Rieder MJ, Chen YD, Rotter JI, Ridker PM, Hopewell JC, Parish S, Armitage J, Collins R, Wilke RA, Nickerson DA, Stephens M, Krauss RM. Mangravite LM, et al. Nature. 2013 Oct 17;502(7471):377-80. doi: 10.1038/nature12508. Epub 2013 Aug 28. Nature. 2013. PMID: 23995691 Free PMC article.

References

1. Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA : the journal of the American Medical Association. 2003;289:1681–1690. - PubMed
1. Mangravite LM, et al. A statin-dependent QTL for GATM expression is associated with statin-induced myopathy. Nature. 2013;502:377–380. - PMC - PubMed
1. Marciante KD, et al. Cerivastatin, genetic variants, and the risk of rhabdomyolysis. Pharmacogenet Genomics. 2011;21:280–288. - PMC - PubMed
1. Floyd JS, et al. A screening study of drug-drug interactions in cerivastatin users: an adverse effect of clopidogrel. Clin Pharmacol Ther. 2012;91:896–904. - PMC - PubMed
1. Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis. The New England journal of medicine. 2002;346:539–540. - PubMed

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GATM locus does not replicate in rhabdomyolysis study

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GATM locus does not replicate in rhabdomyolysis study

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