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Comment
. 2014 Oct 7;111(40):E4137.
doi: 10.1073/pnas.1410781111. Epub 2014 Sep 17.

No evidence for genetic assortative mating beyond that due to population stratification

Abdel Abdellaoui  1 , Karin J H Verweij  2 , Brendan P Zietsch  3
Affiliations
Comment

No evidence for genetic assortative mating beyond that due to population stratification

Abdel Abdellaoui et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The first two ancestry-informative PCs from the PC analysis (PCA) conducted on the European populations from the 1000 Genomes project using Eigenstrat (4). (Left) PCs from a PCA on 1,185,924 of the 1,250,013 ancestry SNPs that correlated significantly (α = 0.05) with any of the first five PCs from Domingue et al. (Right) PCs from the PCA on 433,450 of 457,201 SNPs that were not individually significantly associated with any of the first five PCs, showing very little evidence of population stratification according to Domingue et al. PC1 correlates 0.97 between the two SNP sets, and PC2 correlates 0.92.
See this image and copyright information in PMC

Comment in

  • Reply to Abdellaoui et al.: Interpreting GAM.
    Domingue BW, Fletcher JM, Conley D, Boardman JD. Domingue BW, et al. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4138. doi: 10.1073/pnas.1413105111. Epub 2014 Sep 17. Proc Natl Acad Sci U S A. 2014. PMID: 25232035 Free PMC article. No abstract available.

Comment on

References

    1. Domingue BW, Fletcher J, Conley D, Boardman JD. Genetic and educational assortative mating among US adults. Proc Natl Acad Sci USA. 2014;111(22):7996–8000. - PMC - PubMed
    1. Bossard JH. Residential propinquity as a factor in marriage selection. Am J Sociol. 1932;38(2):219–224.
    1. Brittingham A, De La Cruz GP. Ancestry: 2000. Washington, DC: US Department of Commerce, Economics and Statistics Administration, US Census Bureau; 2004.
    1. Price AL, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38(8):904–909. - PubMed
    1. Abdellaoui A, et al. Population structure, migration, and diversifying selection in the Netherlands. Eur J Hum Genet. 2013;21(11):1277–1285. - PMC - PubMed

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