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Review
. 2014 Sep 14;20(34):12018-25.
doi: 10.3748/wjg.v20.i34.12018.

Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients

Theodoros Eleftheriadis  1 , Georgios Pissas  1 , Georgia Antoniadi  1 , Vassilios Liakopoulos  1 , Ioannis Stefanidis  1
Affiliations
Review

Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients

Theodoros Eleftheriadis et al. World J Gastroenterol. .

Abstract

Hepatitis B virus (HBV) is a major global health problem. Despite the success of the general measures against blood transmitted infections in hemodialysis (HD) units, the prevalence of HBV infection among the HD patients is still high. Thus vaccination against HBV is indicating in this population. However, compared with the general population the seroprotection achieved in HD patients remains relatively low, at about 70%. In this review patient, HD procedure and vaccine-associated factors that affect the efficacy of HBV vaccination are analyzed. Also alternative routes of HBV vaccine administration as well as new and more immunogenic vaccine formulations are discussed. However, besides scientific progress, vigilance of HD physicians and staff regarding the general measures against the transmission of blood borne infections and the vaccination against HBV is also required for reducing the prevalence of this viral infection.

Keywords: Adjuvant; Hemodialysis; Hepatitis B virus epidemiology; Hepatitis B virus vaccine; Immunostimulant; Intradermal.

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References

    1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 2004;11:97–107. - PubMed
    1. Burdick RA, Bragg-Gresham JL, Woods JD, Hedderwick SA, Kurokawa K, Combe C, Saito A, LaBrecque J, Port FK, Young EW. Patterns of hepatitis B prevalence and seroconversion in hemodialysis units from three continents: the DOPPS. Kidney Int. 2003;63:2222–2229. - PubMed
    1. Johnson DW, Dent H, Yao Q, Tranaeus A, Huang CC, Han DS, Jha V, Wang T, Kawaguchi Y, Qian J. Frequencies of hepatitis B and C infections among haemodialysis and peritoneal dialysis patients in Asia-Pacific countries: analysis of registry data. Nephrol Dial Transplant. 2009;24:1598–1603. - PubMed
    1. Wang C, Sun J, Zhu B, Larsen S, Yu R, Wu J, Zhao W. Hepatitis B virus infection and related factors in hemodialysis patients in China - systematic review and meta-analysis. Ren Fail. 2010;32:1255–1264. - PubMed
    1. Bergervoet PW, van Riessen N, Sebens FW, van der Zwet WC. Application of the forensic Luminol for blood in infection control. J Hosp Infect. 2008;68:329–333. - PubMed

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