Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Aug 15;7(8):1923-30.
eCollection 2014.

The association between B vitamins supplementation and adverse cardiovascular events: a meta-analysis

Wen-Feng Li  1 , Dan-Dan Zhang  2 , Ji-Tian Xia  1 , Shan-Fan Wen  3 , Jun Guo  1 , Zi-Cheng Li  1
Affiliations
Review

The association between B vitamins supplementation and adverse cardiovascular events: a meta-analysis

Wen-Feng Li et al. Int J Clin Exp Med. .

Abstract

This study is to explore the association of adverse cardiovascular events with B vitamins supplementation. Rev.Man 5.1 and Stata 11.0 software were applied for the meta-analysis. The number of cardiovascular events was collected and calculated using indicates of odds ratio and 95% confidence intervals in a fixed-effects or a random-effects model when appropriate. The study includes 15 studies which consists of 37,358 study objects (experimental group: 19,601; control group: 17,757). This study showed that the pooled ORs was 1.01 (95% CI = 0.96~1.06, P > 0.05) for objects with Experimental group (B vitamins supplementation) vs. Control group (placebo or regular treatment), which suggests no significant differences were found in the overall effect of the number of cardiovascular events between the two groups. Further stratification of subgroup analysis indicates no significant differences were found between the two groups as well. There were also no publication bias existing by the Egger's linear regression test (P > 0.05). Our result indicates that the number of cardiovascular events in experimental group using B vitamins supplementation during the treatment is equal to placebo or regular treatment group thus further studies is necessary.

Keywords: B vitamins supplementation; cardiovascular events; folic acid; meta-analysis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow diagram for the selection of studies.
Figure 2
Figure 2
Forest plot of cardiovascular events with experimental group vs. control group.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Purwanto , Eswaran C, Logeswaran R. Prediction models for early risk detection of cardiovascular event. J Med Syst. 2012;36:521–31. - PubMed
    1. Hermes W, Franx A, van Pampus MG, Bloemenkamp KW, van der Post JA, Porath M, Ponjee G, Tamsma JT, Mol BW, de Groot CJ. 10-Year cardiovascular event risks for women who experienced hypertensive disorders in late pregnancy: the HyRAS study. BMC Pregnancy Childbirth. 2010;10:28. - PMC - PubMed
    1. Suarez C, Zeymer U, Limbourg T, Baumgartner I, Cacoub P, Poldermans D, Röther J, Bhatt DL, Steg PG REACH Registry Investigators. Influence of polyvascular disease on cardiovascular event rates. Insights from the REACH Registry. Vasc Med. 2010;15:259–65. - PubMed
    1. Carballo D, Auer R, Carballo S, Windecker S, Matter C, Luscher T, Vogt P, Perneger T, Mach F, Rodondi N, Keller PF SPUM-ACS. [A Swiss multicentric project to improve the prevention of cardiovascular event recurrence after acute coronary syndromes] . Rev Med Suisse. 2010;6:518, 520–2, 524. - PubMed
    1. Bhatt DL, Eagle KA, Ohman EM, Hirsch AT, Goto S, Mahoney EM, Wilson PW, Alberts MJ, D'Agostino R, Liau CS, Mas JL, Röther J, Smith SC Jr, Salette G, Contant CF, Massaro JM, Steg PG REACH Registry Investigators. Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA. 2010;304:1350–7. - PubMed

LinkOut - more resources