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Review
. 2014 Sep 4:5:418.
doi: 10.3389/fimmu.2014.00418. eCollection 2014.

Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides

Ellis L Reinherz  1 , Derin B Keskin  1 , Bruce Reinhold  1
Affiliations
Review

Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides

Ellis L Reinherz et al. Front Immunol. .

Abstract

Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen's proteome could greatly impact infectious diseases and cancers. Enabling this potential are recent advances in mass spectrometry that identify specific target peptides among the myriad HLA-bound peptides on altered cells. Ultrasensitivity of these physical detection methods allows for the direct assessment of peptide presentation on small numbers of tissue-derived cells. In addition, concurrent advances in immunobiology suggest ways to induce CTLs with requisite functional avidity and tissue deployment. Elicitation of high-avidity resident-memory T cells through vaccination may shift the vaccinology paradigm both for preventive and therapeutic approaches to human disease control.

Keywords: CTL; T cell epitopes; TCR; mass spectrometry; proteomics; resident-memory T cells; vaccines.

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Figure 1
Essential components of efficacious CD8 vaccine development.
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