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. 2014 Sep 12;3(5):3.
doi: 10.1167/tvst.3.5.3. eCollection 2014 Sep.

Assessment of Central Retinal Sensitivity Employing Two Types of Microperimetry Devices

Hongting Liu  1 , Millena G Bittencourt  2 , Jiangxia Wang  3 , Raafay Sophie  2 , Rachel Annam  2 , Mohamed A Ibrahim  4 , Yasir J Sepah  4 , Ahmadreza Moradi  2 , Hendrik P N Scholl  2 , Quan Dong Nguyen  4
Affiliations

Assessment of Central Retinal Sensitivity Employing Two Types of Microperimetry Devices

Hongting Liu et al. Transl Vis Sci Technol. .

Abstract

Purpose: To compare the retinal sensitivity measurements obtained with two microperimeters, the Micro-Perimeter 1 (MP-1) and the Optos optical coherence tomography (OCT)/scanning laser ophthalmoscope (SLO) in subjects with and without maculopathies.

Methods: Forty-five eyes with no known ocular disease and 47 eyes with maculopathies were examined using both microperimeters. A contrast-adjusted scale was applied to resolve the different stimuli and background luminance existing between the two devices.

Results: There was a strong ceiling effect with the MP-1 in the healthy group, with 90.1% (1136 of 1260) test points clustered at 20 dB. The mean sensitivity for the corresponding points in the OCT/SLO was 25.8 ± 1.9 dB. A floor effect was also observed with the OCT/SLO in the maculopathy group with 9.7% (128 of 1316) points clustered at 9-dB values. The corresponding mean sensitivity in the MP-1 was 1.7 ± 3.9 dB. A regression equation between the two microperimeters was established in the common 10 to19 dB intervals as: OCT/SLO = 15.6 + 0.564 × MP-1 - 0.009 × MP-12 + k (k is an individual point constant; MP-1 coefficient P < 0.001; MP-12 coefficient P = 0.006).

Conclusion: The OCT/SLO and the MP-1 provide two different ranges of contrasts for microperimetry examination. Broadening the dynamic range may minimize the constraint of the ceiling and floor effect. There is a significant mathematical relationship in the common interval of the contrast scale.

Translational relevance: Applying a unified and broadened dynamic range in different types of microperimeters will help to generate consistent clinical reference for measurements.

Keywords: comparison; microperimetry; retinal sensitivity.

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Figures

Figure 1.
Figure 1.
The Polar 3 pattern consists of a total of 28 points located in three concentric rings centered on the fovea. The inner ring consisted of 4 points; the middle ring and the outer ring consisted of 12 points (2.3°, 6.6°, and 11° in diameter, respectively). Each value of the 28 points represents the light sensitivity for the corresponding retinal area. The sensitivity scale ranged from 0 dB (lowest sensitivity) to 20 dB (highest sensitivity).
Figure 2.
Figure 2.
Distribution pattern of sensitivities and ceiling/floor effect of microperimetry.
Figure 3.
Figure 3.
The original and predicted OCT/SLO values by the regression equation.
Figure 4.
Figure 4.
The Relationship of OCT/SLO and MP1 at Different Locations
See this image and copyright information in PMC

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