doi: 10.1039/c4cc04383a.
Epub 2014 Sep 19.
Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan
Affiliations
- PMID: 25237679
- DOI: 10.1039/c4cc04383a
Item in Clipboard
Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan
Chem Commun (Camb).
.
Abstract
Herein, we report natural chitosan end-capped MCM-41 type MSNPs as novel, dual stimuli, responsive nano-vehicles for controlled anticancer drug delivery. The chitosan nanovalves tightly close the pores of the MSNPs to control premature cargo release under physiological conditions but respond to lysozyme and acidic media to release the trapped cargo.
Similar articles
-
Chitosan-capped mesoporous silica nanoparticles as pH-responsive nanocarriers for controlled drug release.Chem Asian J. 2014 Jan;9(1):319-27. doi: 10.1002/asia.201301105. Epub 2013 Oct 2. Chem Asian J. 2014. PMID: 24115568
-
Natural gelatin capped mesoporous silica nanoparticles for intracellular acid-triggered drug delivery.Langmuir. 2013 Oct 15;29(41):12804-10. doi: 10.1021/la4022646. Epub 2013 Oct 3. Langmuir. 2013. PMID: 24073830
-
Capped mesoporous silica nanoparticles as stimuli-responsive controlled release systems for intracellular drug/gene delivery.Expert Opin Drug Deliv. 2010 Sep;7(9):1013-29. doi: 10.1517/17425247.2010.498816. Expert Opin Drug Deliv. 2010. PMID: 20716017 Review.
-
Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment.Artif Cells Nanomed Biotechnol. 2018 Feb;46(1):75-81. doi: 10.1080/21691401.2017.1290648. Epub 2017 Feb 23. Artif Cells Nanomed Biotechnol. 2018. PMID: 28278578
-
Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery.Expert Opin Drug Deliv. 2015 Feb;12(2):319-37. doi: 10.1517/17425247.2014.953051. Epub 2014 Nov 25. Expert Opin Drug Deliv. 2015. PMID: 25421898 Review.
Cited by
-
Polyaspartic acid-anchored mesoporous silica nanoparticles for pH-responsive doxorubicin release.Int J Nanomedicine. 2018 Feb 19;13:1029-1040. doi: 10.2147/IJN.S146955. eCollection 2018. Int J Nanomedicine. 2018. PMID: 29497295 Free PMC article.
-
Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery.Pharmaceutics. 2023 Jan 29;15(2):447. doi: 10.3390/pharmaceutics15020447. Pharmaceutics. 2023. PMID: 36839771 Free PMC article. Review.
-
Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy.Pharmaceutics. 2022 May 23;14(5):1113. doi: 10.3390/pharmaceutics14051113. Pharmaceutics. 2022. PMID: 35631699 Free PMC article. Review.
-
Recent Advance on Mesoporous Silica Nanoparticles-Based Controlled Release System: Intelligent Switches Open up New Horizon.Nanomaterials (Basel). 2015 Nov 25;5(4):2019-2053. doi: 10.3390/nano5042019. Nanomaterials (Basel). 2015. PMID: 28347110 Free PMC article. Review.
-
Nanoformulation Composed of Ellagic Acid and Functionalized Zinc Oxide Nanoparticles Inactivates DNA and RNA Viruses.Pharmaceutics. 2021 Dec 16;13(12):2174. doi: 10.3390/pharmaceutics13122174. Pharmaceutics. 2021. PMID: 34959455 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
