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Comment
. 2014 Sep 18;41(3):345-347.
doi: 10.1016/j.immuni.2014.09.001.

Targeting foxp1 for reinstating anticancer immunosurveillance

Laurence Zitvogel  1 , Guido Kroemer  2
Affiliations
Free article
Comment

Targeting foxp1 for reinstating anticancer immunosurveillance

Laurence Zitvogel et al. Immunity. .
Free article

Abstract

Transforming growth factor β (TGF-β) is a canonical immunosuppressive cytokine secreted by tumors. In this issue of Immunity, Stephen et al. (2014) reveal that tumor-derived TGF-β deactivates antitumor CD8(+) T cell responses through T cell upregulation of the FoxP1 transcription factor.

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