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Comment
. 2014 Sep 18;55(6):805-806.
doi: 10.1016/j.molcel.2014.09.003.

IRAK4 activation: a cautious embrace

Stevan R Hubbard  1
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Free article
Comment

IRAK4 activation: a cautious embrace

Stevan R Hubbard. Mol Cell. .
Free article

Abstract

Structural and biochemical studies by Ferrao et al. (2014) in this issue demonstrate that dimerization of the kinase domain of IRAK4 is crucial for its activation, but with conditions: after-not before-receptor recruitment and before-not after-autophosphorylation.

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