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Review
. 2014 Nov;237(1):92-8.
doi: 10.1016/j.atherosclerosis.2014.08.054. Epub 2014 Sep 6.

The role of T cells in the development of cardiovascular disease in HIV-infected patients

Affiliations
Review

The role of T cells in the development of cardiovascular disease in HIV-infected patients

M Krikke et al. Atherosclerosis. 2014 Nov.

Abstract

Cardiovascular disease (CVD) is highly prevalent in HIV-infected patients. Besides the classical cardiovascular risk factors, HIV related factors play a role, such as immune activation and treatment with highly active antiretroviral therapy (HAART). The resulting T cell activation is regarded as one of the driving forces behind this accelerated atherogenesis. Interventions, such as early treatment and anti-inflammatory therapy, decreasing T cell activation might lead to a lower incidence of CVD in future HIV infected patients. This review specifically explores the role of T cells in the development of atherosclerosis in HIV-infected patients.

Keywords: Atherosclerosis; CD4+ T cells; CD8+ T cells; Cardiovascular disease; Coagulation markers; Endothelial markers; HIV; HIV-infection; Immune activation; Inflammatory markers; Monocyte activation; Monocytes; T cell activation.

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