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Review
. 2015 Aug;38(4):431-6.
doi: 10.1097/COC.0000000000000123.

Hepatocellular carcinoma: can circulating tumor cells and radiogenomics deliver personalized care?

Richard L Hesketh  1 , Andrew X Zhu, Rahmi Oklu
Affiliations
Review

Hepatocellular carcinoma: can circulating tumor cells and radiogenomics deliver personalized care?

Richard L Hesketh et al. Am J Clin Oncol. 2015 Aug.

Abstract

The 'omics revolution is facilitating a personalized approach to improving outcome by refining diagnosis, staging, treatment, and monitoring of hepatocellular carcinoma. Furthermore, the promise of being able to target a range of specific tumor drivers at a molecular level offers exciting new therapy prospects for a disease that is notoriously difficult to treat. We provide a unique perspective combining our understanding of the molecular mechanisms of hepatocellular carcinoma development with the potential of circulating tumor cells and radiogenomics to change the drivers of decision-making used in current practice.

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Figures

Fig. 1
Fig. 1. A proposed algorithm for incorporating CTCs and radiogenomics into screening, diagnosis and management of HCC
The inset shows the potential applications of CTCs and the principle of radiogenomics: creating an association map between imaging traits and microarray data to allow prediction of gene expression based solely on the imaging traits. IHC – immunohistochemistry. aCGH – array comparative genomic hybridization.
See this image and copyright information in PMC

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