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Review
. 2014 Sep;46 Suppl 1(0 1):S11-21.
doi: 10.1007/s11255-014-0808-9. Epub 2014 Sep 20.

Pathophysiology and animal modeling of underactive bladder

Pradeep Tyagi  1 , Phillip P Smith, George A Kuchel, William C de Groat, Lori A Birder, Christopher J Chermansky, Rosalyn M Adam, Vincent Tse, Michael B Chancellor, Naoki Yoshimura
Affiliations
Review

Pathophysiology and animal modeling of underactive bladder

Pradeep Tyagi et al. Int Urol Nephrol. 2014 Sep.

Abstract

While the symptomology of underactive bladder (UAB) may imply a primary dysfunction of the detrusor muscle, insights into pathophysiology indicate that both myogenic and neurogenic mechanisms need to be considered. Due to lack of proper animal models, the current understanding of the UAB pathophysiology is limited, and much of what is known about the clinical etiology of the condition has been derived from epidemiological data. We hereby review current state of the art in the understanding of the pathophysiology of and animal models used to study the UAB.

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Conflict of interest statement

Conflict of interest Vincent Tse has conflicts of interest related to Allergan, Astellas, and American Medical Systems. Michael B Chancellor has conflicts of interest related to Allergan, Astellas, Cook, Lipella, Medtronic, Pfizer, Targacept. There are no conflicts of interest for Pradeep Tyagi, William C. de Groat, Lori A. Birder, Christopher J. Chermansky, Rosalyn M. Adam, George A. Kuchel, Philip P. Smith and Naoki Yoshimura.

Figures

Fig. 1
Fig. 1
Diabetes-induced urethral dysfunction contributes to incomplete voiding. In these experiments, striated sphincter activity was suppressed by α-bungarotoxin and NO-mediated urethral relaxation was suppressed by L-NAME. Diabetic rat shows significantly reduced urethral pressure profile compared with normal rat
Fig. 2
Fig. 2
Schematic illustration for rat model of Iatrogenic UAB-induced by brief bilateral pelvic nerve crush in adult female rats with a straight micro-mosquito clamp
Fig. 3
Fig. 3
Cystometric outcomes of bilateral pelvic nerve crush in female rats. Compared with sham group, the crush injury of pelvic nerves exhibited increases in PVR and decreases in maximum voiding pressure and voiding efficiency
See this image and copyright information in PMC

References

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