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. 2015 Apr;54(4):655-9.
doi: 10.1093/rheumatology/keu361. Epub 2014 Sep 19.

Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome?

Dennis Lendrem  1 , Sheryl Mitchell  2 , Peter McMeekin  2 , Luke Gompels  2 , Katie Hackett  1 , Simon Bowman  2 , Elizabeth Price  2 , Colin T Pease  2 , Paul Emery  2 , Jacqueline Andrews  2 , Peter Lanyon  2 , John Hunter  2 , Monica Gupta  2 , Michele Bombardieri  2 , Nurhan Sutcliffe  2 , Costantino Pitzalis  2 , John McLaren  2 , Annie Cooper  2 , Marian Regan  2 , Ian Giles  2 , David Isenberg  2 , Vadivelu Saravanan  2 , David Coady  2 , Bhaskar Dasgupta  2 , Neil McHugh  2 , Steven Young-Min  2 , Robert Moots  2 , Nagui Gendi  2 , Mohammed Akil  2 , Bridget Griffiths  2 , Wan-Fai Ng  1 ; UK primary Sjögren’s Syndrome Registry
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Free article

Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome?

Dennis Lendrem et al. Rheumatology (Oxford). 2015 Apr.
Free article

Abstract

Objective: This study sets out to investigate the relationship between health status [EuroQol five-dimensions questionnaire (EQ-5D)] in primary SS and three of the European League Against Rheumatism (EULAR) SS outcome measures-the disease activity index (ESSDAI), the patient reported index (ESSPRI) and the sicca score. In particular, the goal was to establish whether there is a relationship between the EULAR outcome measures and quality of life.

Methods: Health status was evaluated using a standardized measure developed by the EuroQol Group-the EQ5D. This permits calculation of two measures of health status: time trade-off (TTO) values and the EQ-5D visual analogue scale (VAS) scores. We used Spearman's rank correlation analysis to investigate the strength of association between health status and three EULAR measures of physician- and patient-reported disease activity in 639 patients from the UK primary SS registry (UKPSSR) cohort.

Results: This study demonstrates that the EULAR SS disease-specific outcome measures are significantly correlated with health outcome values (P < 0.001). Higher scores on the ESSDAI, EULAR sicca score and ESSPRI are associated with poorer health states-i.e. lower TTO values and lower VAS scores. While all three are significantly correlated with TTO values and EQ-5D VAS scores, the effect is strongest for the ESSPRI.

Conclusion: This study provides further evidence supporting the use of ESSDAI, EULAR sicca score and ESSPRI measures in the clinic. We also discuss the need for disease-specific measures of health status and their comparison with standardized health outcome measures.

Keywords: disease activity; outcome measures; patient-reported outcomes; primary Sjögren’s syndrome; quality of life; utility values.

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