Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jun 12;21(22):2334-2338.
doi: 10.1002/adma.200900018.

Light-Induced Content Release from Plasmon Resonant Liposomes

Timothy S Troutman  1 , Sarah J Leung  1 , Marek Romanowski  1
Affiliations

Light-Induced Content Release from Plasmon Resonant Liposomes

Timothy S Troutman et al. Adv Mater. .
No abstract available

Keywords: Biomedical Materials; Core/Shell Materials; Hybrid Materials; Nanostructures; Optically Active Materials.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic representation of the formation of plasmon resonant shell and subsequent content release. A water-soluble agent is encapsulated in thermosensitive liposomes. Gold coating is introduced by reduction of ionic gold in the presence of liposomes. The density with which gold clusters are produced on the liposome surface controls the spectral position of resulting plasmon resonance. When illuminated at the wavelength matching plasmon resonance, the energy of absorbed light is converted into heat so the thermosenstive liposomes release their content.
Figure 2
Figure 2
Extinction spectra of liposome preparations. Bare liposome suspension loaded with fluorescein (solid), gold-coated liposome suspension resonant at 655 nm loaded with fluorescein (dashed), gold-coated liposome suspension resonant at 971 nm loaded with fluorescein (dotted), gold-coated liposome suspension without fluorescein (dash-dot).
Figure 3
Figure 3
Liposome content release induced by temperature. Data and fitted curves are shown for bare liposomes (inverted triangle, dotted), gold-coated liposomes resonant at 655 nm (open circle, dashed), and gold-coated liposomes resonant at 971 nm (closed circle, solid line). The data were modeled with a sum of two Gaussian functions yielding initial release at 29 and 31 °C for bare liposomes and coated liposomes, respectively. The level of initial release was 35, 24, and 19 % from uncoated, on-resonant, and off-resonant liposome suspensions respectively. Complete release was observed at 45 and 47 °C for bare liposomes and coated liposomes, respectively. Error bars represent average of the three standard deviations acquired at 6, 24 and 46 °C.
Figure 4
Figure 4
(A–C) Light-induced release of liposome contents. Data and fitted curves are shown for gold-coated liposomes resonant at 971 nm (A), 655 nm (B), and bare liposomes (C). The response of each liposome type to light was modeled with a four-parameter logistic function, with 50 % release observed at 12, 84, and 100 J of cumulative energy for on-resonant, off-resonant and non-coated liposome suspensions respectively. Error bars represent the average of the three standard deviations acquired at cumulative energy levels of 0.38, 14.65, and 221.9 J. (D–F) Peak temperatures recorded during light induced release, for gold-coated liposomes resonant at 971 nm (D), 655 nm (E), and bare liposomes (F) is shown. Error bars represent the standard deviations at cumulative energy levels of three trials.
See this image and copyright information in PMC

References

    1. Langer R, Tirrel DA. Nature. 2004;428:487. - PubMed
    1. de Fougerolles A, Vornlocher HP, Maraganore J, Lieberman J. Nature Rev. 2007;6:443. - PMC - PubMed
    1. Allen TM, Cullis PR. Science. 2004;303:1818. - PubMed
    1. Yatvin MB, Kreutz W, Horwitz BA, Shinitzky M. Science. 1980;210:1253. - PubMed
    1. Hafez IM, Cullis PR. Methods Enzymol. 2004;387:113. - PubMed

LinkOut - more resources