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. 1989 Mar;12(3):205-7.
doi: 10.1007/BF03349963.

Raised plasma levels of atrial natriuretic peptides in Addison's disease

F P Cappuccio  1 , N D Markandu, M G Buckley, A L Sugden, G A Sagnella, G A MacGregor
Affiliations

Raised plasma levels of atrial natriuretic peptides in Addison's disease

F P Cappuccio et al. J Endocrinol Invest. 1989 Mar.

Abstract

Plasma levels of atrial natriuretic peptides (ANP) were significantly higher in 7 patients with treated Addison's disease (15.8 +/- 8.8 pg/ml, mean +/- SD) than in 7 control subjects (6.1 +/- 3.8 pg/ml) matched for sex, age, body weight and blood pressure. All subjects were studied on their usual sodium intake and had similar urinary sodium excretions. These findings indicate inappropriately high levels of plasma ANP in patients with treated Addison's disease and are possibly due to the lack of adrenal control on ANP synthesis and/or secretion in these patients.

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