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Randomized Controlled Trial
. 2014 Sep 22:9:212.
doi: 10.1186/1748-717X-9-212.

A comparison of concurrent chemoradiotherapy and radiotherapy in Chinese patients with locally advanced cervical carcinoma: a multi-center study

Zhijie Li, Shuyan Yang, Lei Liu, Shiyu Han  1
Affiliations
Randomized Controlled Trial

A comparison of concurrent chemoradiotherapy and radiotherapy in Chinese patients with locally advanced cervical carcinoma: a multi-center study

Zhijie Li et al. Radiat Oncol. .

Abstract

Background: We investigated the efficacy of concurrent chemoradiotherapy (CCRT) over radiotherapy (RT) in Chinese patients with locally advanced cervical carcinoma.

Patients and methods: Between January 2005 and January 2008, 192 patients with squamous cell carcinoma of the cervix were included in the study: 96 in arm A (CCRT with 20 mg/m2 cisplatin for 5 days) and 96 in arm B (RT). The overall response rate was the primary endpoint. The secondary endpoints included overall survival, progression-free survival, and toxicity.

Results: The 5-year overall response rate was 67% and 53% for the CCRT and RT arms, respectively, and the difference was statistically significant, while the median overall survival was 68 months (range 3-85 months) and 61 months (range 4-83 months), respectively (P = 0.009). In addition, the median progression-free survival for CCRT was 62 months (range 3-83 months), whereas it was 51 months (range 4-81 months) for the RT arm (P = 0.025). The toxicity profile, both acute and late, was comparable in both arms.

Conclusion: In summary, we demonstrate that CCRT was effective and better tolerated than RT alone in Chinese patients with locally advanced cervical carcinoma.

Trial registration: Chinese Clinical Trials Register: ChiCTR-TRC-13003979.

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Figures

Figure 1
Figure 1
Flow of participants through trial.
Figure 2
Figure 2
Overall survival.
Figure 3
Figure 3
Progression-free survival.
See this image and copyright information in PMC

References

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