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Review
. 2014 Aug;21(3):163-7.
doi: 10.11005/jbm.2014.21.3.163. Epub 2014 Aug 31.

Factors and mechanisms involved in the coupling from bone resorption to formation: how osteoclasts talk to osteoblasts

Kyoji Ikeda  1 , Sunao Takeshita  1
Affiliations
Review

Factors and mechanisms involved in the coupling from bone resorption to formation: how osteoclasts talk to osteoblasts

Kyoji Ikeda et al. J Bone Metab. 2014 Aug.

Abstract

Bone remodeling is the fundamental means by which the quality as well as quantity of the skeleton is maintained throughout adult life. When bone remodeling goes awry, a metabolic bone disease such as osteoporosis ensues. Among multiple phases of the complex remodeling process, we focus in this review on factors and mechanisms that are involved in the coupling of bone formation to preceding resorption.

Keywords: Bone remodeling; Bone resorption; Osteoblasts; Osteoclasts.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Complement component 3a (C3a) and collagen triple helix repeat containing 1 (Cthrc1) in the communication between osteoclasts (OC) and osteoblasts (OB). Bone marrow macrophages (BMM) become committed preOC and then mature, multinucleated OC (mOC). C3a is derived from mOC and acts on bone marrow stromal cells (BMSC) to stimulation osteoblastogenesis. Cthrc1 is secreted from mature active OC (maOC) in the middle of bone resorption and stimulates OB differentiation as well as recruitment of BMSC or mesenchymal stem cells (MSC) to resorption lacunae.
See this image and copyright information in PMC

References

    1. Zaidi M. Skeletal remodeling in health and disease. Nat Med. 2007;13:791–801. - PubMed
    1. Parfitt AM. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem. 1994;55:273–286. - PubMed
    1. Tang Y, Wu X, Lei W, et al. TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med. 2009;15:757–765. - PMC - PubMed
    1. Xian L, Wu X, Pang L, et al. Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Nat Med. 2012;18:1095–1101. - PMC - PubMed
    1. Martin TJ, Sims NA. Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med. 2005;11:76–81. - PubMed