Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Sep;87(3):113-7.
doi: 10.4174/astr.2014.87.3.113. Epub 2014 Aug 26.

The clinical features and optimal treatment of anorectal malignant melanoma

Soomin Nam  1 , Chang Woo Kim  1 , Se Jin Baek  1 , Hyuk Hur  1 , Byung Soh Min  1 , Seung Hyuk Baik  1 , Nam Kyu Kim  1
Affiliations
Review

The clinical features and optimal treatment of anorectal malignant melanoma

Soomin Nam et al. Ann Surg Treat Res. 2014 Sep.

Abstract

Anorectal malignant melanoma (AMM) is a very rare and aggressive disease. The purpose of this article is to review the clinical features of AMM, to understand treatment options, and optimal therapy by reviewing pertinent literature. Traditionally an abdominoperineal resection (APR) sacrificing the anal sphincter has been performed for radical resection of cancer, but recently, wide excision of AMM is attempted since quality of life after surgery is an important issue. Some authors reported that there was no difference in five-year survival between the patient who underwent an APR and wide excision. The goal of both APR and wide excision was to improve survival with R0 resection. Adjuvant chemoradiation therapy can be performed to achieve an R0 resection. AMM shows very poor prognosis. At this time, research on AMM is insufficient to suggest a treatment guideline. Thus, treatment options, and a therapeutic method should be selected carefully.

Keywords: Anal neoplasms; Melanoma; Skin neoplasms; Surgery; Wide local excision.

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

References

    1. Falch C, Stojadinovic A, Hann-von-Weyhern C, Protic M, Nissan A, Faries MB, et al. Anorectal malignant melanoma: extensive 45-year review and proposal for a novel staging classification. J Am Coll Surg. 2013;217:324–335. - PubMed
    1. Ishizone S, Koide N, Karasawa F, Akita N, Muranaka F, Uhara H, et al. Surgical treatment for anorectal malignant melanoma: report of five cases and review of 79 Japanese cases. Int J Colorectal Dis. 2008;23:1257–1262. - PubMed
    1. Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011;61:212–236. - PubMed
    1. International Ageny for Research on Cancer. Malignant melanoma of skin [Internet] Lyon: International Ageny for Research on Cancer; c2012. [cited 2014 Mar 14]. Available from: http://eu-cancer.iarc.fr/EUCAN/Cancer.aspx?Cancer=20.
    1. National Cancer Center, Center for Cancer Control and Information Services. Cancer Statistics in Japan [Internet] Tokyo: National Cancer Center, Center for Cancer Control and Information Services; [cited 2014 Mar 14]. Available from: http://ganjoho.jp/pro/statistics/en/table_download.html.

LinkOut - more resources