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Review
. 2014:110:153-87.
doi: 10.1016/B978-0-12-405943-6.00004-X.

E proteins in lymphocyte development and lymphoid diseases

Ian Belle  1 , Yuan Zhuang  2
Affiliations
Review

E proteins in lymphocyte development and lymphoid diseases

Ian Belle et al. Curr Top Dev Biol. 2014.

Abstract

As members of the basic helix-loop-helix (bHLH) family of transcription factors, E proteins function in the immune system by directing and maintaining a vast transcriptional network that regulates cell survival, proliferation, differentiation, and function. Proper activity of this network is essential to the functionality of the immune system. Aberrations in E protein expression or function can cause numerous defects, ranging from impaired lymphocyte development and immunodeficiency to aberrant function, cancer, and autoimmunity. Additionally, disruption of inhibitor of DNA-binding (Id) proteins, natural inhibitors of E proteins, can induce additional defects in development and function. Although E proteins have been investigated for several decades, their study continues to yield novel and exciting insights into the workings of the immune system. The goal of this chapter is to discuss the various classical roles of E proteins in lymphocyte development and highlight new and ongoing research into how these roles, if compromised, can lead to disease.

Keywords: B cell; Burkitt Lymphoma; Development; E2A; HEB; Id2; Id3; Sjogren's Syndrome; T cell.

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Figures

Figure 4.1
Figure 4.1
Diagram of B cell development. Major developmental events involving E proteins and major E protein targets are indicated.
Figure 4.2
Figure 4.2
Diagram of T cell development. Major developmental events involving E proteins and major E protein targets are indicated.
See this image and copyright information in PMC

References

    1. Alexander EL, Arnett FC, Provost TT, & Stevens MB (1983). Sjögren’s syndrome: Association of anti-Ro (SS-A) antibodies with vasculitis, hematologic abnormalities, and serologic hyperreactivity. Annals of Internal Medicine, 98(2), 155–159. - PubMed
    1. Alexander E, Hirsch T, Arnett F, Provost T, & Stevens M (1981). Ro (SSA) and La (SSB) antibodies in the clinical spectrum of Sjogren’s syndrome. The Journal of Rheumatology, 9(2), 239–246. - PubMed
    1. Anderson G, Jenkinson EJ, Moore NC, & Owen JJ (1993). MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature, 362, 70–73. - PubMed
    1. Aronheim A, Shiran R, Rosen A, & Walker MD (1993). The E2A gene product contains two separable and functionally distinct transcription activation domains. Proceedings of the National Academy of Sciences, 90(17), 8063–8067. - PMC - PubMed
    1. Austin TW, Solar GP, Ziegler FC, Liem L, & Matthews W (1997). A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells. Blood, 89(10), 3624–3635. - PubMed

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